Unlike European grapes, muscadines must be picked one at a time, rather than in clusters, and the stem separates from the fruit, which reduces shelf life somewhat. One bit, however, and you'll wonder why you waste your money on those flavorless marbles they call grapes at the grocery store. Just as with tomatoes, there is simply no comparison to a vine ripened fruit and the easy to ship, but green and bland varieties you find in the store.
With other nectar sources nearly non-existent due to the lack of rain, however, you have to be doubly careful as you reach into the leaves and grab the ripe ones - some had small holes drilled in and were occupied by honeybees or a small bumblebee (and sometimes both) and have been covered in yellow jackets in some years. Although easy to dislodge by shaking, accidentally grabbing one of these valuable pollinators will invariably mean a nasty sting.